Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ka 1648 0.0 1.0 0.122 0.213
biological_process rf 1648 0.0 1.0 0.127 0.214
cellular_component ka 1649 0.0 0.993 0.243 0.269
cellular_component rf 1649 0.0 0.984 0.239 0.27
disease ka 1462 0.0 1.0 0.044 0.145
disease rf 1462 0.0 0.999 0.045 0.143
genetic_interaction_weighted ka 1668 0.0 0.998 0.316 0.271
genetic_interaction_weighted rf 1668 0.0 0.998 0.317 0.272
molecular_function ka 1634 0.0 1.0 0.35 0.292
molecular_function rf 1634 0.0 0.997 0.331 0.304
pathway ka 653 0.001 1.0 0.543 0.492
pathway node2vec 653 0.0 0.999 0.322 0.347
pathway rf 653 0.001 1.0 0.332 0.41
protein_interaction_unweighted ka 1657 0.0 1.0 0.304 0.455
protein_interaction_unweighted node2vec 1657 0.0 1.0 0.142 0.22
protein_interaction_unweighted rf 1657 0.0 0.926 0.066 0.154

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 0.978 0.162 0.272
integration_mean_by_presence el 1676 0.0 0.944 0.412 0.262
integration_mean_by_presence ka 1676 0.0 1.0 0.069 0.154
integration_mean_by_presence rf 1676 0.0 0.914 0.055 0.12
mean ct 1676 0.0 0.978 0.132 0.244
mean el 1676 0.0 0.965 0.215 0.251
mean ka 1676 0.0 1.0 0.041 0.125
mean rf 1676 0.0 0.919 0.046 0.108

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels

NO DATA